MATERIAL SAFETY DATA SHEET
PROTAMEX, SOLID
3. HAZARDS IDENTIFICATION
Harmful if inhaled. Granulated enzymes are coated to prevent formation of enzyme dust. Inappropriate
handling may release dust. Inhalation of enzyme dust or aerosols resulting from inappropriate handling
may induce respiratory sensitization and may cause allergic reactions in sensitized individuals. See
"Other Health Effects" Section. Can decompose at high temperatures forming toxic gases.
EMERGENCY OVERVIEW:
POTENTIAL HEALTH EFFECTS
Inhalation of enzyme aerosol by susceptible individuals may result in allergic sensitization. May cause
respiratory sensitization or other allergic responses. May cause shortness of breath, wheezing,
coughing and sneezing. See Section 11, "Other Studies Relevant to Material".
Inhalation:
Prolonged, confined (especially under the finger nails, under rings or watch bands) or repeated
exposure may cause skin irritation. May cause defatting, drying and cracking of the skin. Prolonged and
repeated contact may lead to dermatitis.
Skin Contact:
Not applicable.
Skin Absorption:
EMERGENCY TELEPHONE NUMBERS (FOR EMERGENCIES INVOLVING CHEMICAL SPILLS OR RELEASE)
Toronto, ON (416) 226-6117 Montreal, QC (514) 861-1211 Winnipeg, MB (204) 943-8827
Edmonton, AB (780) 424-1754 Calgary, AB (403) 263-8660 Vancouver, BC (604) 685-5036
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Brenntag Canada Inc.
43 Jutland Rd.
Toronto, ON
M8Z 2G6
(416) 259-8231
Website: http:\\www.brenntag.ca
WHMIS#:
00066311
Index:
2007 October 12
PRODUCT IDENTIFICATION
Protamex, Solid.
Product Name:
2007 October 12
Date of Revision:
Effective Date:
HCI5451/07D
Protease.
Chemical Name:
Protamex.
Synonyms:
Enzyme Preparation (Protein).
Chemical Family:
Not applicable.
Molecular Formula:
Food additive. Food processing aid. Catalyst. Industrial application.
Product Use:
WHMIS Classification / Symbol:
READ THE ENTIRE MSDS FOR THE COMPLETE HAZARD EVALUATION OF THIS PRODUCT.
D-2A: Very Toxic (respiratory sensitizer)
Ingredient
CAS#
ACGIH TLV
% Concentration
2. COMPOSITION, INFORMATION ON INGREDIENTS (Not Intended As Specifications)
Protease
9001-92-7
—
1 - 10
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 2 of 7
4. FIRST AID MEASURES
FIRST AID PROCEDURES
Move victim to fresh air. Give artificial respiration ONLY if breathing has stopped. Give
cardiopulmonary resuscitation (CPR) if there is no breathing AND no pulse. Obtain medical attention
IMMEDIATELY.
Inhalation:
Start flushing while removing contaminated clothing. Wash affected areas thoroughly with soap and
water. If irritation, redness, or a burning sensation develops and persists, repeat flushing and obtain
medical attention.
Skin Contact:
Immediately flush eyes thoroughly for 5 minutes with running water. Hold eyelids open during flushing.
If irritation persists, repeat flushing. Obtain medical attention.
Eye Contact:
Do not attempt to give anything by mouth to an unconscious person. If victim is alert and not
convulsing, rinse mouth out and give 1/2 to 1 glass of water to dilute material. DO NOT induce
vomiting. If spontaneous vomiting occurs, have victim lean forward with head down to avoid breathing
in of vomitus, rinse mouth and administer more water. Obtain medical attention IMMEDIATELY.
Ingestion:
Medical supervision of all employees who handle or come in contact with respiratory sensitizers is
recommended. This should include preemployment and periodic medical examinations with respiratory
function tests (forced expiratory volume, forced vital capacity as a minimum). Persons with asthmatic-
type conditions, chronic bronchitis, other chronic respiratory diseases or recurrent skin eczema or
sensitization should be excluded from working with this product. Once a person is diagnosed as
sensitized, no further exposure to any sensitizer should be permitted.
Medical conditions that may be aggravated by exposure to this product include allergies to enzyme
proteins ( asthma ).
Note to Physicians:
Excessive contact with powder may cause drying of mucous membranes of the eyes due to absorption
of moisture and oils. This product may cause irritation, redness and possible damage due to
abrasiveness.
Eye Contact:
This product may cause mild gastrointestinal discomfort.
Ingestion:
Effects (irritancy) on the skin and eyes may be delayed, and damage may occur without the sensation
or onset of pain. Strict adherence to first aid measures following any exposure is essential.
Other Health Effects:
5. FIRE-FIGHTING MEASURES
Flashpoint (°C)
AutoIgnition
Temperature (°C)
LEL
UEL
Flammability Limits in Air (%):
Not available.
Not available.
Not available.
Not available.
Not regulated.
Flammability Class (WHMIS):
Thermal decomposition products are toxic and may include oxides of carbon.
Hazardous Combustion
Products:
Avoid accumulation and dispersion of dust to reduce explosion potential. Spilled material may cause
floors and contact surfaces to become slippery.
Unusual Fire or Explosion
Hazards:
Not expected to be sensitive to mechanical impact.
Sensitivity to Mechanical Impact:
Not available.
Rate of Burning:
Not available.
Explosive Power:
Expected to be sensitive to static discharge when vapours are present between the lower and upper
explosive limits.
Sensitivity to Static Discharge:
EXTINGUISHING MEDIA
Use media appropriate for surrounding fire and/or materials.
Fire Extinguishing Media:
FIRE FIGHTING
INSTRUCTIONS
Isolate materials that are not involved in the fire and protect personnel. Clean up immediately to
eliminate slipping hazard. Do not allow to enter sewers or watercourses. Avoid accumulation and
dispersion of dust to reduce explosion potential.
Instructions to the Fire Fighters:
Use self-contained breathing apparatus and protective clothing.
Fire Fighting Protective
Equipment:
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 3 of 7
6. ACCIDENTAL RELEASE MEASURES
Information in this section is for responding to spills, leaks or releases in order to prevent or minimize the adverse effects on persons,
property and the environment. There may be specific reporting requirements associated with spills, leaks or releases, which change from
region to region.
In all cases of leak or spill contact vendor at Emergency Number shown on the front page of this MSDS.
Wear protective clothing. Avoid accumulation and dispersion of dust to reduce explosion potential.
Avoid creating dusts/aerosols. Avoid dry sweeping. Spilled material may cause floors and contact
surfaces to become slippery. Take up be a mechanical means preferably by a vacuum cleaner
equipped with a high efficiency filter. Collect product for recovery or disposal. Ventilate enclosed
spaces. Notify applicable government authority if release is reportable or could adversely affect the
environment.
Containment and Clean-Up
Procedures:
7. HANDLING AND STORAGE
HANDLING
Use normal "good" industrial hygiene and housekeeping practices. Clean up immediately to eliminate
slipping hazard. This product is treated to minimize the formation of dust. Follow Good Manufacturing
Practices (GMP) when handling or storing this product.
Immobilized enzymes are enzymes bound to a stable, insoluble matrix which also secure a low level of
enzyme dust. Inappropriate handling may release dust. Inhalation of enzyme dust or aerosols resulting
from inappropriate handling may induce respiratory sensitization and may cause allergic reactions in
sensitized individuals.
Handling Practices:
See Section 8, "Engineering Controls".
Ventilation Requirements:
Use only with adequate ventilation and avoid breathing dusts. Avoid contact with eyes, skin or clothing.
Wash thoroughly with soap and water after handling. Wash contaminated clothing thoroughly before re-
use.
Other Precautions:
STORAGE
Ideal storage temperature is 5 to 10 °C. Do not expose sealed containers to temperatures above 40
Deg. Celsius. Storage above 40 Deg. Celsius will see diminishment of product quality.
Storage Temperature (°C):
General exhaust is acceptable.
Ventilation Requirements:
Store in a cool, dry and well-ventilated area. Keep away from heat, sparks and flames. Keep
containers closed. Avoid moisture contamination. Prolonged storage may result in lumping or caking.
Protect from direct sunlight.
Storage Requirements:
Materials of construction for storing the product include: fiber drum. Confirm suitability of any material
before using.
Special Materials to be Used for
Packaging or Containers:
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Recommendations listed in this section indicate the type of equipment, which will provide protection against overexposure to this
product. Conditions of use, adequacy of engineering or other control measures, and actual exposures will dictate the need for specific
protective devices at your workplace.
ENGINEERING CONTROLS
Local exhaust ventilation required. Make up air should be supplied to balance air that is removed by
local or general exhaust ventilation. Avoid accumulation and dispersion of dust to reduce explosion
potential. Ventilate low lying areas such as sumps or pits where dense dust may collect.
Engineering Controls:
PERSONAL PROTECTIVE
EQUIPMENT (PPE)
Safety glasses with side shields are recommended to prevent eye contact. Use dust-tight chemical
safety goggles when there is potential for eye contact. Contact lenses should not be worn when working
with this material.
Eye Protection:
Gloves and protective clothing made from PVC or rubber or plastic should be impervious under
conditions of use. Prior to use, user should confirm impermeability. Discard contaminated gloves.
Skin Protection:
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 4 of 7
No specific guidelines available. A NIOSH/MSHA-approved air-purifying respirator equipped with dust,
mist, fume cartridges for concentrations up to 100 mg/m³ particulate. An air-supplied respirator if
concentrations are higher or unknown.
If while wearing a respiratory protection, you can smell, taste or otherwise detect anything unusual, or in
the case of a full facepiece respirator you experience eye irritation, leave the area immediately. Check
to make sure the respirator to face seal is still good. If it is, replace the filter, cartridge or canister. If
the seal is no longer good, you may need a new respirator. (4)
Respiratory Protection:
Wear an impermeable apron and boots. Locate safety shower and eyewash station close to chemical
handling area. Take all precautions to avoid personal contact.
Manufacturer's Recommended Exposure Level : 0.00006 mg/m³. (3)
Other Personal Protective
Equipment:
Particulate Not Otherwise Classified:
ACGIH OSHA
10 mg/m³ - Inhalable particulate 50 mppcf* or 15 mg/m³ - Total Dust
3 mg/m³ - Respirable particulate 15 mppcf* or 5 mg/m³ - Respirable Fraction
* mppcf = million particles per cubic foot
EXPOSURE GUIDELINES
Solid.
Light brown granulate.
Typical fermentation odour.
Not available.
Not available.
Not available.
Not applicable.
Not applicable.
Not available.
Not available.
Not applicable.
Not applicable.
Soluble in water.
Not applicable.
Not applicable.
Not applicable.
Not applicable.
Physical State:
Appearance:
Odour:
Odour Threshold (ppm):
Boiling Range (°C):
Melting/Freezing Point (°C):
Vapour Pressure (mm Hg at 20° C):
Vapour Density (Air = 1.0):
Relative Density (g/cc):
Bulk Density:
Viscosity:
Evaporation Rate (Butyl Acetate = 1.0):
Solubility:
% Volatile by Volume:
pH:
Coefficient of Water/Oil Distribution:
Volatile Organic Compounds (VOC):
9. PHYSICAL AND CHEMICAL PROPERTIES (Not intended as Specifications)
11. TOXICOLOGICAL INFORMATION
TOXICOLOGICAL DATA:
10. STABILITY AND REACTIVITY
CHEMICAL STABILITY
Stable.
Under Normal Conditions:
Not flammable.
Under Fire Conditions:
Will not occur.
Hazardous Polymerization:
High temperatures, sparks, open flames and all other sources of ignition. Avoid accumulation and
dispersion of dust to reduce explosion potential.
Conditions to Avoid:
Strong oxidizers. Lewis or mineral acids. Strong bases. Do not store in humid places. Avoid direct
sunlight.
Materials to Avoid:
Thermal decomposition products are toxic and may include oxides of carbon.
Decomposition or Combustion
Products:
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 5 of 7
SUBSTANCE
LD50 (Oral, Rat)
LD50 (Dermal, Rabbit)
LC50 (Inhalation, Rat, 4h)
Protease
> 2 000 mg/kg (3)
---
---
The ingredient(s) of this product is (are) not classed as carcinogenic by ACGIH, IARC, OSHA or NTP.
Carcinogenicity Data:
No adverse reproductive effects are anticipated.
Reproductive Data:
No adverse mutagenic effects are anticipated.
Mutagenicity Data:
No adverse teratogenic effects are anticipated.
Teratogenicity Data:
This product may cause respiratory sensitization or other allergic responses. Sensitization is the
process whereby a biological change occurs in the individual because of previous exposure to a
substance and, as a result, the individual reacts more strongly when subsequently exposed to the
substance. Once sensitized, an individual can react to extremely low airborne levels, even below the
TLV, or to skin contact. See Section 11, "Other Studies Relevant to Material".
Respiratory / Skin Sensitization
Data:
None known.
Synergistic Materials:
Inhalation of enzyme aerosol by susceptible individuals may result in allergic sensitization. Symptoms,
which can be delayed by up to twelve hours after exposure, may include hay fever-like reactions such
as runny eyes and nose, cough, chest tightness and shortness of breath. (3)
Other Studies Relevant to
Material:
12. ECOLOGICAL INFORMATION
LC50 (Fish) = Above 100 mg/L (3)
EC50 (Daphnia) = Above 100 mg/L (3)
Ecotoxicity:
This product is biodegradable. Do not contaminate domestic or irrigation water supplies, lakes, streams,
ponds, or rivers.
Environmental Fate:
13. DISPOSAL CONSIDERATIONS
Not available.
Deactivating Chemicals:
This information applies to the material as manufactured. Reevaluation of the product may be required
by the user at the time of disposal since the product uses, transformations, mixtures and processes
may influence waste classification. Dispose of waste material at an approved (hazardous) waste
treatment/disposal facility in accordance with applicable local, provincial and federal regulations. Do not
dispose of waste with normal garbage, or to sewer systems.
Waste Disposal Methods:
See "Waste Disposal Methods".
Safe Handling of Residues:
Empty containers retain product residue and can be hazardous. Treat package in the same manner as
the product.
Disposal of Packaging:
14. TRANSPORTATION INFORMATION
CANADIAN TDG ACT SHIPPING DESCRIPTION:
This product is not regulated by TDG.
Label(s): Not applicable. Placard: Not applicable.
ERAP Index: -----.
Exemptions: None known.
US DOT CLASSIFICATION (49CFR 172.101, 172.102):
This product is not regulated by DOT.
Label(s): Not applicable. Placard: Not applicable.
CERCLA-RQ: Not available.
Exemptions: None known.
15. REGULATORY INFORMATION
CANADA
This product is exempted from the DSL and is covered by the Canadian Food and Drug Act.
CEPA - NSNR:
Not included.
CEPA - NPRI:
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 6 of 7
The use of this material/product as a food additive is regulated by Health and Welfare Canada in the
Food and Drug Act and the Food and Drug Regulations. It is incumbent on the user of this
material/product to ensure any intended food application is consistent with Health and Welfare Canada
guidelines. Food Grade designation in no way implies that the product is safe for consumption by
humans. (3)
CANADIAN FOOD AND DRUG
ACT/REGULATIONS:
Controlled Products Regulations Classification (WHMIS):
D-2A: Very Toxic (respiratory sensitizer)
USA
This product is exempted from the TSCA inventory under the US-EPA and is covered by the US FDA.
Environmental Protection Act:
Respiratory Sensitizer.
OSHA HCS (29CFR 1910.1200):
This material/product is regulated for use by the US FDA. It is incumbent on the user of this
material/product to ensure any intended food application is consistent with US FDA guidelines. Food
Grade designation in no way implies that the product is safe for consumption by humans. (3)
U.S. FOOD AND DRUG
ADMINISTRATION:
Text22:
NFPA: 1 Health, 1 Fire, 0 Reactivity (6)
Text22:
HMIS: 1 Health, 1 Fire, 0 Reactivity (3)
INTERNATIONAL
Not available.
16. OTHER INFORMATION
REFERENCES
RTECS-Registry of Toxic Effects of Chemical Substances, Canadian Centre for Occupational Health and Safety RTECS
database.
1.
Clayton, G.D. and Clayton, F.E., Eds., Patty's Industrial Hygiene and Toxicology, 3rd ed., Vol. IIA,B,C, John Wiley and Sons,
New York, 1981.
2.
Supplier's Material Safety Data Sheet(s).
3.
CHEMINFO, through "CCINFOdisc", Canadian Centre for Occupational Health and Safety, Hamilton, Ontario, Canada.
4.
Guide to Occupational Exposure Values, 2005, American Conference of Governmental Industrial Hygienists, Cincinnati, 2005.
5.
Regulatory Affairs Group, Brenntag Canada Inc.
6.
The British Columbia Drug and Poison Information Centre, Poison Managements Manual, Canadian Pharmaceutical
Association, Ottawa, 1981.
7.
____________________________________________________________________________________________________________
The information contained herein is offered only as a guide to the handling of this specific material and has been prepared in good faith
by technically knowledgeable personnel. It is not intended to be all-inclusive and the manner and conditions of use and handling may
involve other and additional considerations. No warranty of any kind is given or implied and Brenntag Canada Inc. will not be liable for
any damages, losses, injuries or consequential damages which may result from the use of or reliance on any information contained
herein. This Material Safety Data Sheet is valid for three years.
____________________________________________________________________________________________________________
To obtain revised copies of this or other Material Safety Data Sheets, contact your nearest Brenntag Canada Regional office.
British Columbia: 20333-102B Avenue, Langley, BC, V1M 3H1
Phone: (604) 513-9009 Facsimile: (604) 513-9010
Alberta: 6628 - 45 th. Street, Leduc, AB, T9E 7C9
Phone: (780) 986-4544 Facsimile: (780) 986-1070
Manitoba: 681 Plinquet Street, Winnipeg, MB, R2J 2X2
Phone: (204) 233-3416 Facsimile: (204) 233-7005
Ontario: 43 Jutland Road, Toronto, ON, M8Z 2G6
Phone: (416) 259-8231 Facsimile: (416) 259-5333
Quebec: 2900 Jean Baptiste Des., Lachine, PQ, H8T 1C8
Phone: (514) 636-9230 Facsimile: (514) 636-0877
Atlantic: A-105 Akerley Boulevard, Dartmouth, NS, B3B 1R7
Phone: (902) 468-9690 Facsimile: (902) 468-3085
____________________________________________________________________________________________________________
Protamex, Solid
Brenntag Canada Inc.
Date of Revision:
2007 October 12
WHMIS Number :
00066311
Page 7 of 7
Prepared By: Regulatory Affairs Group, Brenntag Canada Inc., (416) 259-8231.