Elanco Animal Health
Spinosad Pour-On
Effective Date : 18-Nov-2003
Section 1 - Chemical Product and Company
Manufacturer:
Elanco Animal Health
Division of Eli Lilly and Company
2001 West Main St
PO Box 708
Greenfield, IN 46140
Manufacturer's Emergency Phone:
1-800-428-444I
CHEMTREC :
1-800-424-9300 (North America)
1-703-527-3887 (International)
Common Name: Spinosad Pour-On
Chemical Name: 1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-methyl-
alpha-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino)
tetrahydro-6-methyl-2H-pyran-2-yl]oxy-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-
tetradecahydro-14-methyl-, (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-
Chemical Name 2: 1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 2-[(6-deoxy-2,3,4-tri-O-
methyl-alpha-L-mannopyranosyl)oxy]-13-[[(2R,5S,6R)-5-(dimethylamino) tetrahydro-6-methyl-2H-
pyran-2-yl]oxy-9-ethyl-2,3,3 a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecaydro-
4,14-dimethyl- (2S,3aR,5aS,5bS,9S,13S,14R,16aS,16bS)-
Synonym(s) : 232105 formulation ; Spinosad formulation ; Spinosad pour-on for sheep and cattle
See attached glossary for abbreviations.
Section 2 - Composition / Information on Ingredients
Ingredient

CAS
Concentration
Spinosyn A
131929-60-7
a
Spinosyn D
131929-63-0
-
a
Propylene Glycol
57-55-6
20
Trimethylnonanol Polyethylene Glycol
60828-78-6
10
Lactic Acid
50-21-5
0 .5
Polyethylene Glycols
25322-68-3
0 .3
2,6,8-Trimethyl-4-nonanol
123-17-1
0.2
Polydimethylsiloxane
63148-62-9
0.3
Propyl Gallate
121-79-9
0.1
Water
7732-18-5
> 65
a - Spinosyn A and Spinosyn D combine to make Spinosad which accounts for 2% of the formulation .
Exposure Guidelines:
Spinosad - Dow AgroSciences Exposure Guideline 0.3 mg/m3 TWA.
Propylene glycol - WEEL 50 ppm TWA (total vapor and aerosol), 10 mg/m3 (aerosol only) TWA for 8
hours .
UK - Exposure Standard 10 mg/m3 TWA (particulates), 150 ppm (474 mg/m3) TWA (vapor and
particulates) .
Ireland - Occupational Exposure Limit 10 mg/m3 TWA (particulates) 150 ppm (470 mg/m3) TWA
(total vapor and particulates) .
Section 3 - Hazards Identification
Appearance: Blue, clear low viscosity liquid
Physical State : Liquid
Odor: Earthy
Emergency Overview
Emergency Overview Effective Date: 07-Jun-2002
Lilly Laboratory Labeling Codes:
Health 2

Fire 1
Reactivity 0
Primary Physical and Health Hazards: Irritant (eyes) . Liver, Kidney and Bone Marrow Effects .
Caution Statement: Spinosad Pour-On may be irritating to the eyes . Effects of exposure to Spinosad
Pour-On may include liver, kidney, and bone marrow tissue changes .
Routes of Entry: Inhalation and skin contact.
Effects of Overexposure: May be severely irritating to the eyes . May cause slight skin
irritation . Animal studies with high doses of spinosad reported tissue changes in the liver, kidney, and
bone marrow .
Medical Conditions Aggravated by Exposure: None known .
Carcinogenicity :
Spinosad (spinosynA and spinosyn D) - Not listed by IARC, NTP, ACGIH, or OSHA. Did not cause
cancer in long term animal studies .
Propylene glycol - Not listed by IARC, NTP, ACGIH, or OSHA. Multiple long term dietary, inhalation,
and dermal studies demonstrated no evidence of carcinogenicity in mice, rabbits, or rats .
Remaining ingredients - Not listed by IARC, NTP, ACGIH, orOSHA.
Section 4 - First Aid Measures
Eyes : Flush eyes with plenty of water. Get medical attention .
s
Skin : Remove contaminated clothing and clean before reuse . Wash all exposed areas of skin with
plenty of soap and water . Get medical attention if irritation develops .
Inhalation : Move individual to fresh air . Get medical attention if breathing difficulty occurs . Ifnot
breathing, provide artificial respiration assistance (mouth-to-mouth) and call a physician immediately .
Ingestion: Do not induce vomiting . Call a physician or poison control center. If available, administer
activated charcoal (6-8 heaping teaspoons) with two to three glasses of water. Do not give anything by
mouth to an unconscious person . Immediately transport to a medical care facility and see a physician .
Section 5 - Fire Fighting Measures
Flash Point: >62 C (>144 F)
FLash Method: Pensky-Martin Closed Tester
UEL: No applicable information found
LEL: No applicable information found
Extinguishing Media: Use water, carbon dioxide, dry chemical, foam, or Halon .
Unusual Fire and Explosion Hazards: Slight fire hazard when exposed to heat or flame .
Hazardous Combustion Products : May emit toxic fumes when exposed to heat or fire .
Section 6 - Accidental Release Measures
Spills : Prevent further migration into the environment . Use absorbent/adsorbent material to solidify
liquids . Sweep up or vacuum . Wear protective equipment, including eye protection, to avoid exposure
(see Section 8 for specific handling precautions) . Large spills due to traffic accidents, etc ., should be
reported immediately to CHEMTREC and Elanco Animal Health for assistance, Prevent spilled
material from flowing onto adjacent land or into streams, ponds, or lakes .
Section 7 - Handling and Storage
Storage Conditions : Store at room temperature . Product should not be used after the date printed on
the container . Warehouse : 10 to 40 C (45 to 104 F).
Section 8 - Exposure Controls / Personal Protection
See Section 2 for Exposure Guideline information .
When mixing and handling, use protective clothing, impervious gloves, and dust respirator. Operators
should wash thoroughly with soap and water after handling . If accidental eye contact occurs,
immediately rinse with plenty of water .
Respiratory Protection : Use an approved respirator .
4
Eye Protection : Safety glasses or goggles .
Ventilation : Laboratory fume hood or local exhaust ventilation .
Other Protective Equipment : In a manufacturing setting, wear chemical-resistant gloves and body
covering to minimize skin contact. If handled in a ventilated enclosure, as in a laboratory setting,
respirator and goggles or face shield may not be required . Safety glasses are always required .
Additional Exposure Precautions : Under normal use and handling conditions, wear goggles to protect
eyes and wear impermeable gloves and protective equipment to avoid direct contact with skin . Wash
thoroughly with soap and water after handling .
Section 9 - Physical and Chemical Properties
Appearance: Blue, clear low viscosity liquid
Odor: Earthy

Boiling Point: No applicable information found
Melting Point: No applicable information found
Specific Gravity : 1 .023
pH: 4 to 4.1
Evaporation Rate : No applicable information found
Water Solubility: Soluble
Vapor Density: No applicable information found
Vapor Pressure : No applicable information found
Section 10 - Stability and Reactivity
Stability : Stable at normal temperatures and pressures .
Incompatibility : May react with strong oxidizing agents (e.g ., peroxides, permanganates, nitric acid,
etc.) .
Hazardous Decomposition : May emit toxic fumes when heated to decomposition .
Hazardous Polymerization : Will not occur .
Section 11 - Toxicological Information
Acute Exposure
Oral :
Spinosad pour-on - Rat, median lethal dose between 5000 mg/kg and 20000 mg/kg.
Skin :
Spinosad pour-on - Rabbit, median lethal dose greater than 1000 mg/kg .
InhaLation :
Spinosad - Rat, median lethal concentration greater than 5180 mg/m3 for 4 hours .
Propylene glycol - Dog, 313 g/m3 to 627 g/m3 for 15 minutes, no deaths or toxicity .
Dimethylsiloxane - Rabbit, median lethal concentration 978 g/m3 for 7.5 hours, no deaths .
Skin Contact:
Spinosad pour-on - Rabbit, nonirritant
Eye Contact:
Spinosad pour-on - Rabbit, severe irritant (reversible)
Chronic Exposure
Target Organ Effects :
Spinosad - In animals, has been shown to cause vacuolation of cells in liver, kidney, and bone tissues
and changes in blood and serum biochemistry . Dose levels producing these effects were many times
higher than any dose levels expected from exposure due to use,
Polyethylene glycol - Kidney effects (decreased weight, tissue changes) .
Other Effects :
Spinosad - Decreased activity, leg weakness, and intermittent tremors were reported in a female dog
given oral doses of 200 mg/kg/day for 5 days . These effects were not observed in the male dog .
Reproduction :
Spinosad - In laboratory animal studies, effects on reproduction have been seen only at doses that
produced significant toxicity to the parent animals .
Polyethylene glycol - Decreased offspring survival and fetal weight at doses toxic to the mother .
Polydimethylsiloxane - No effects identified in limited animal studies .
Sensitization :
Spinosad pour-on - Did not cause allergic skin reactions when tested in guinea pigs .
Mutagenicity:
Spinosad - Not mutagenic in bacterial or mammalian cells .
Propylene glycol - In vitro mutagenicity studies were negative . Animal mutagenicity studies were
negative .
Polydimethylsiloxane - Not mutagenic in bacterial or mammalian cells .
Section 12 - Ecological Information
No environmental data for the mixture or formulation . The environmental information for ingredient(s)
or related material(s) are presented .
Environmental Summary :
Spinosad - Highly toxic to honey bees, oysters, and diatoms . Moderately toxic to blue-green
algae. Slightly to moderately toxic to fish and aquatic invertebrates . No more than slightly to
practically nontoxic to birds. Practically nontoxic to green algae . No volatility expected . Does not
bioconcentrate in aquatic organisms . Not persistent due to photolysis and biodegradation.
Propylene glycol - Practically non-toxic to aquatic organisms . Material is not expected to bioconcentrate
in aquatic organisms . Material may leach from soil into groundwater . Material is expected to be
degraded by microorganisms . Biodegraation is expected to be achievable in secondary waste water
treatment plant. Material is not expected to readily evaporate ; however, once in the atmosphere it is
expected to rapidly degrade (within minutes to hours) .
Polydimethylsiloxane - Material is toxic to slightly toxic to aquatic organisms . Material can be
considered immobile in soil . Material is not expected to be degraded in water, air, or soil by light or
microorganisms . Material is considered persistent in the environment .
Section 13 - Disposal Considerations
Waste Disposal : Dispose of any cleanup materials and waste residue according to all applicable laws
and regulations .
Container Disposal : No special package disposal required .
Section 14 - Transport Information
Regulatory Organizations :
DOT: Not Regulated
ICAO/IATA: Not Regulated
IMO : Not Regulated
Section 15 - Regulatory Information
Below is selected regulatory information chosen primarily for possible Elanco Animal Health
usage . This section is not a complete analysis or reference to all applicable regulatory
information . Please consider all applicable laws and regulations for your country/state .
U.S. Regulations
Spinosad (spinosyn A and spinosyn D)
TSCA - No
CERCLA - Not on this list
SARA 302 - Not on this list
SARA 313 - Not on this list
OSHA Substance Specific - No
Remaining Ingredients
TSCA - Yes
CERCLA - Not on this list
SARA 302 - Not on this list
SARA 313 - Not on this list
OSHA Substance Specific - No
EU Regulations
EC Classification
Xi (Irritant)
Risk Phrases
R 36 - Irritating to eyes .
Safety Phrases
S 25 - Avoid contact with eyes .
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
Section 16 - Other Information
MSDS Sections Revised: Sections 1 and 16.
As of the date of issuance, we are providing available information relevant to the handling of this
material in the workplace . All information contained herein is offered with the good faith beliefthat it is
accurate . THIS MATERIAL SAFETY DATA SHEET SHALL NOT BE DEEMED TO CREATE ANY
WARRANTY OF ANY KIND (INCLUDING WARRANTY OF MERCHANTABILITY OR FITNESS
FORA PARTICULAR PURPOSE) . In the event ofan adverse incident associated with this material,
this safety data sheet is' not intended to be a substitute for consultation with appropriately trained
personnel . Nor is this safety data sheet intended to be a substitute for product literature which may
accompany the finished product .
For additional information contact :
ELANCO Animal Health
1-800-428-4441
1-317-276-2000
GLOSSARY:
ACGIH = American Conference of Governmental Industrial Hygienists
AIHA = American Industrial Hygiene Association
BEI = Biological Exposure Index
CAS Number = Chemical Abstract Service Registry Number
CERCLA = Comprehensive Environmental Response Compensation and Liability Act (of 1980)
CHAN = Chemical Hazard Alert Notice
CHEMTREC = Chemical Transportation Emergency Center
DOT = Department of Transportation
EC = European Community
EINECS = European Inventory of Existing Chemical Substances
ELINCS = European List of New Chemical Substances
EPA = Environmental Protection Agency
HEPA = High Efficiency Particulate Air (Filter)
IARC = International Agency for Research on Cancer
ICAO/IATA = International Civil Aviation Organization/International Air Transport Ass_ ociation
IEG = Lilly Interim Exposure Guideline

,
IMO = International Maritime Organization
Kow = Octanol/Water Partition Coefficient
LEG = Lilly Exposure Guideline
LEL = Lower Explosive Limit
MSDS = Material Safety Data Sheet
MSHA = Mine Safety and Health Administration
NA = Not Applicable, except in Section 14 where NA = North America
NADA = New Animal Drug Application
NAIF =No Applicable Information Found
NCI = National Cancer Institute
NIOSH = National Institute for Occupational Safety and Health
NOS = Not Otherwise Specified
NTP = National Toxicology Program
OSHA = Occupational Safety and Health Administration
PEL = Permissible Exposure Limit (OSHA)
RCRA = Resource Conservation and Recovery Act
RQ = Reportable Quantity ,
RTECS = Registry ofToxic Effects of Chemical Substances
SARA = Superfund Amendments and Reauthorization Act
STEG = Lilly Short Term Exposure Guideline
STEL = Short Term Exposure Limit
TLV = Threshold Limit Value (ACGIH)
TPQ = Threshold Planning Quantity
TSCA = Toxic Substances Control Act
TWA = Time Weighted Average/8 Hours Unless Otherwise Noted
UEL = Upper Explosive Limit
UN = United Nations
WEEL = Workplace Environmental Exposure Level (AIHA)