Ether
AETHER; ANAESTHETIC ETHER; ANESTHESIA ETHER; ANESTHETIC ETHER;
DIAETHYLAETHER (GERMAN); DIETHYL ETHER; DIETHYL OXIDE; DWUETYLOWY
ETER (POLISH); ETERE ETILICO (ITALIAN); ETHER; ETHER (DOT); ETHER, ETHYL
(DOT); ETHER ETHYLIQUE (FRENCH); ETHOXYETHANE; ETHYL ETHER; OXYDE
D'ETHYLE (FRENCH); SOLVENT ETHER; SULFURIC ETHER; ETHANE, 1,1'-OXYBIS-
857
1879550
5/16/2008.
5/16/2008.
Material Safety Data Sheet
Product name
Synonym
Manufacturer
Product No.
MSDS #
Validation date
Print date
In case of emergency
Product and company identification
Responsible name
MSDS (Regulatory Affairs)
Ether
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1 .
Chemical formula
: C4H10O
CHEMTREC:
800.424.9300
OUTSIDE US:
202.483.7616
Supplier
: Thermo Fisher Scientific
Pierce Biotechnology
P.O. Box 117
Rockford, IL 61105
United States
815.968.0747 or
800.874.3723
:
Use of
Substance/Preparation
Refer to the instruction booklet for
proper and intended use.
Otherwise, contact supplier for
specific applications.
: Thermo Fisher Scientific
Pierce Biotechnology
P.O. Box 117
Rockford, IL 61105
United States
815.968.0747
800.874.3723
Dermal contact. Eye contact. Inhalation. Ingestion.
Emergency overview
Hazards identification
Routes of entry
Potential acute health effects
No known significant effects or critical hazards.
May cause eye irritation.
Harmful if swallowed.
May cause skin irritation.
Eyes
Skin
Inhalation
Ingestion
Physical state
Liquid. [COLORLESS LIQUID WITH A CHARACTERISTIC PUNGENT, SWEETISH
ODOR. [NOTE: A GAS ABOVE 94 F.]]
DANGER !
EXTREMELY FLAMMABLE LIQUID AND VAPOR. FLAMMABLE. VAPOR MAY
CAUSE FLASH FIRE. MAY BE HARMFUL IF SWALLOWED. CAN CAUSE TARGET
ORGAN DAMAGE.
Extremely flammable liquid. Harmful if swallowed. Keep away from heat, sparks and
flame. Do not ingest. Avoid breathing vapor or mist. Avoid contact with eyes, skin and
clothing. Can cause target organ damage. Use only with adequate ventilation. Keep
container tightly closed and sealed until ready for use. Wash thoroughly after handling.
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Odor
: Characteristic. Pungent. Sweetish.
OSHA/HCS status
: This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
2 .
Potential chronic health effects
Carcinogenicity
: No known significant effects or critical hazards.
Chronic effects
: Can cause target organ damage.
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Hazards identification
2 .
See toxicological information (section 11)
Medical conditions
aggravated by over-
exposure
Pre-existing digestive disorders and disorders involving any other target organs
mentioned in this MSDS as being at risk may be aggravated by over-exposure to this
product.
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Mutagenicity
: No known significant effects or critical hazards.
Teratogenicity
: No known significant effects or critical hazards.
Developmental effects
: No known significant effects or critical hazards.
Fertility effects
: No known significant effects or critical hazards.
Over-exposure signs/symptoms
Ingestion
: No specific data.
Skin
: No specific data.
Eyes
: No specific data.
Inhalation
: No specific data.
Target organs
: Causes damage to the following organs: mucous membranes, upper respiratory tract,
skin, eyes, central nervous system (CNS), eye, lens or cornea.
The substance is classified as dangerous according to Directive 67/548/EEC and its amendments.
Classification
F+; R12
R19
Xn; R22
R66, R67
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Physical/chemical hazards
: Extremely flammable. May form explosive peroxides.
Human health hazards
: Harmful if swallowed. Repeated exposure may cause skin dryness or cracking.
Vapors may cause drowsiness and dizziness.
Ether
60-29-7
98 - 100
Composition/information on ingredients
Name
CAS number
%
United States
3 .
There are no ingredients or additional ingredients present which, within the current knowledge of the supplier and
in the concentrations applicable, are classified as hazardous to health or the environment and hence require
reporting in this section.
Substance/preparation
Substance
:
Ingredient name
CAS
number
%
Classification
EC number
Ether
60-29-7
98 - 100
200-467-2
F+; R12
R19
Xn; R22
R66, R67
[1] [2]
Europe
[1] Substance classified with a health or environmental hazard
[2] Substance with a workplace exposure limit
Occupational exposure limits, if available, are listed in section 8.
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Wash out mouth with water. Remove dentures if any. Move exposed person to fresh
air. Keep person warm and at rest. If material has been swallowed and the exposed
person is conscious, give small quantities of water to drink. Stop if the exposed person
feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do
so by medical personnel. If vomiting occurs, the head should be kept low so that vomit
does not enter the lungs. Get medical attention. Never give anything by mouth to an
unconscious person. If unconscious, place in recovery position and get medical
attention immediately. Maintain an open airway. Loosen tight clothing such as a collar,
tie, belt or waistband.
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting
the upper and lower eyelids. Check for and remove any contact lenses. Get medical
attention if irritation occurs.
Flush contaminated skin with plenty of water. Remove contaminated clothing and
shoes. Continue to rinse for at least 10 minutes. Get medical attention if symptoms
occur. Wash clothing before reuse. Clean shoes thoroughly before reuse.
Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if
breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen
by trained personnel. It may be dangerous to the person providing aid to give mouth-to-
mouth resuscitation. Get medical attention. If unconscious, place in recovery position
and get medical attention immediately. Maintain an open airway. Loosen tight clothing
such as a collar, tie, belt or waistband.
First aid measures
Eye contact
Skin contact
Inhalation
Ingestion
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Protection of first-aiders
: No action shall be taken involving any personal risk or without suitable training. It may
be dangerous to the person providing aid to give mouth-to-mouth resuscitation.
See section 11 for more detailed information on health effects and symptoms.
Use dry chemical, CO2, water spray (fog) or foam.
Fire-fighting measures
Extinguishing media
Promptly isolate the scene by removing all persons from the vicinity of the incident if
there is a fire. No action shall be taken involving any personal risk or without suitable
training. Move containers from fire area if this can be done without risk. Use water
spray to keep fire-exposed containers cool.
Extremely flammable liquid. In a fire or if heated, a pressure increase will occur and the
container may burst, with the risk of a subsequent explosion. The vapor/gas is heavier
than air and will spread along the ground. Vapors may accumulate in low or confined
areas or travel a considerable distance to a source of ignition and flash back. Runoff to
sewer may create fire or explosion hazard.
Special protective
equipment for fire-fighters
Fire-fighters should wear appropriate protective equipment and self-contained breathing
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
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Special exposure hazards
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Do not use water jet.
Suitable
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Not suitable
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Hazardous combustion
products
: Decomposition products may include the following materials:
carbon oxides
Flammability of the product
:
No action shall be taken involving any personal risk or without suitable training.
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilled material. Shut off all ignition sources. No
flares, smoking or flames in hazard area. Avoid breathing vapor or mist. Provide
adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put
on appropriate personal protective equipment (see section 8).
Environmental precautions
Accidental release measures
: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers. Inform the relevant authorities if the product has caused environmental
pollution (sewers, waterways, soil or air).
Personal precautions
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6 .
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Accidental release measures
6 .
Stop leak if without risk. Move containers from spill area. Approach release from
upwind. Prevent entry into sewers, water courses, basements or confined areas. Wash
spillages into an effluent treatment plant or proceed as follows. Contain and collect
spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or
diatomaceous earth and place in container for disposal according to local regulations
(see section 13). Use spark-proof tools and explosion-proof equipment. Dispose of via
a licensed waste disposal contractor. Contaminated absorbent material may pose the
same hazard as the spilled product. Note: see section 1 for emergency contact
information and section 13 for waste disposal.
Large spill
:
Stop leak if without risk. Move containers from spill area. Dilute with water and mop up
if water-soluble or absorb with an inert dry material and place in an appropriate waste
disposal container. Use spark-proof tools and explosion-proof equipment. Dispose of
via a licensed waste disposal contractor.
Small spill
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Do not store above the following temperature: -20°C (-4°F). Store in accordance with
local regulations. Store in a segregated and approved area. Store in original container
protected from direct sunlight in a dry, cool and well-ventilated area, away from
incompatible materials (see section 10) and food and drink. Eliminate all ignition
sources. Separate from oxidizing materials. Keep container tightly closed and sealed
until ready for use. Containers that have been opened must be carefully resealed and
kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate
containment to avoid environmental contamination.
Put on appropriate personal protective equipment (see section 8). Eating, drinking and
smoking should be prohibited in areas where this material is handled, stored and
processed. Workers should wash hands and face before eating, drinking and smoking.
Do not breathe vapor or mist. Do not ingest. Avoid contact with eyes, skin and clothing.
Use only with adequate ventilation. Wear appropriate respirator when ventilation is
inadequate. Do not enter storage areas and confined spaces unless adequately
ventilated. Keep in the original container or an approved alternative made from a
compatible material, kept tightly closed when not in use. Store and use away from heat,
sparks, open flame or any other ignition source. Use explosion-proof electrical
(ventilating, lighting and material handling) equipment. Use non-sparking tools. Take
precautionary measures against electrostatic discharges. To avoid fire or explosion,
dissipate static electricity during transfer by grounding and bonding containers and
equipment before transferring material. Empty containers retain product residue and
can be hazardous. Do not reuse container.
Handling and storage
Handling
Storage
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7 .
diethyl ether
ACGIH (United States, 0/2000).
TWA: 400 ppm
STEL: 500 ppm
OSHA (United States, 0/1989).
TWA: 400 ppm
STEL: 500 ppm
ACGIH TLV (United States, 1/2007).
STEL: 1520 mg/m³ 15 minute(s).
STEL: 500 ppm 15 minute(s).
TWA: 1210 mg/m³ 8 hour(s).
TWA: 400 ppm 8 hour(s).
OSHA PEL (United States, 11/2006).
TWA: 1200 mg/m³ 8 hour(s).
TWA: 400 ppm 8 hour(s).
Exposure controls/personal protection
Product name
Exposure limits
United States
8 .
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Exposure controls/personal protection
8 .
OSHA PEL 1989 (United States, 3/1989).
STEL: 1500 mg/m³ 15 minute(s).
STEL: 500 ppm 15 minute(s).
TWA: 1200 mg/m³ 8 hour(s).
TWA: 400 ppm 8 hour(s).
Use a properly fitted, air-purifying or air-fed respirator complying with an approved
standard if a risk assessment indicates this is necessary. Respirator selection must be
based on known or anticipated exposure levels, the hazards of the product and the safe
working limits of the selected respirator.
Safety eyewear complying with an approved standard should be used when a risk
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts.
Personal protective equipment for the body should be selected based on the task being
performed and the risks involved and should be approved by a specialist before handling
this product.
Personal protection
Eyes
Skin
Respiratory
Consult local authorities for acceptable exposure limits.
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Chemical-resistant, impervious gloves complying with an approved standard should be
worn at all times when handling chemical products if a risk assessment indicates this is
necessary.
Hands
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Engineering measures
: Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or
other engineering controls to keep worker exposure to airborne contaminants below any
recommended or statutory limits. The engineering controls also need to keep gas, vapor
or dust concentrations below any lower explosive limits. Use explosion-proof ventilation
equipment.
Hygiene measures
: Wash hands, forearms and face thoroughly after handling chemical products, before
eating, smoking and using the lavatory and at the end of the working period. Appropriate
techniques should be used to remove potentially contaminated clothing. Wash
contaminated clothing before reusing. Ensure that eyewash stations and safety showers
are close to the workstation location.
Recommended monitoring
procedures
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If this product contains ingredients with exposure limits, personal, workplace atmosphere
or biological monitoring may be required to determine the effectiveness of the ventilation
or other control measures and/or the necessity to use respiratory protective equipment.
Environmental exposure
controls
: Emissions from ventilation or work process equipment should be checked to ensure they
comply with the requirements of environmental protection legislation. In some cases,
fume scrubbers, filters or engineering modifications to the process equipment will be
necessary to reduce emissions to acceptable levels.
Europe
diethyl ether
EU OEL (Europe, 5/2006). Notes: Indicative
short term: 616 mg/m³ 15 minute(s).
short term: 200 ppm 15 minute(s).
8 hours: 308 mg/m³ 8 hour(s).
8 hours: 100 ppm 8 hour(s).
Liquid. [COLORLESS LIQUID WITH A CHARACTERISTIC PUNGENT, SWEETISH
ODOR. [NOTE: A GAS ABOVE 94 F.]]
Colorless.
Physical and chemical properties
Physical state
Color
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Flash point
: Closed cup: -45.1°C (-49.2°F)
180°C (356°F)
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Auto-ignition temperature
Flammable limits
: Lower: 1.9%
Upper: 36%
9 .
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Physical and chemical properties
9 .
35.05°C (95.1°F)
-116.06°C (-176.9°F)
0.7135
2.55 [Air = 1]
58.9 kPa (442 mm Hg)
Partially soluble in the following materials: cold water and hot water.
74.1 g/mole
Characteristic. Pungent. Sweetish.
Boiling/condensation point
Melting/freezing point
11.8 ((n-BUTYL ACETATE=1) = 1)
Molecular weight
Relative density
Vapor pressure
Vapor density
Evaporation rate
Solubility
Odor
C4H10O
Molecular formula
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Octanol/water partition
coefficient
: 0.82
The product is stable. Under normal conditions of storage and use, hazardous
polymerization will not occur.
Highly reactive or incompatible with the following materials: oxidizing materials
Will not occur.
Under normal conditions of storage and use, hazardous decomposition products should
not be produced.
Avoid all possible sources of ignition (spark or flame). Do not pressurize, cut, weld,
braze, solder, drill, grind or expose containers to heat or sources of ignition. Do not
allow vapor to accumulate in low or confined areas.
Stability and reactivity
Chemical stability
Conditions to avoid
Incompatible materials
Hazardous decomposition
products
Possibility of hazardous
reactions
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10 .
Toxicological information
United States
11 .
Acute toxicity
diethyl ether
LD50 Dermal
Rabbit
>20 mL/kg
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LD50 Oral
Rat
1215 mg/kg
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Product/ingredient name
Result
Species
Dose
Exposure
Conclusion/Summary
: Not available.
Chronic toxicity
Conclusion/Summary
: Not available.
Carcinogenicity
Conclusion/Summary
: Not available.
Mutagenicity
Conclusion/Summary
: Not available.
Teratogenicity
Conclusion/Summary
: Not available.
Reproductive toxicity
Classification
diethyl ether
-
3
-
None.
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Product/ingredient name
ACGIH
EPA
NIOSH
NTP
IARC
OSHA
Europe
Not available.
Conclusion/Summary
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Toxicological information
11 .
IDLH
: 1900 ppm
Prolonged or repeated contact can defat the skin and lead to irritation, cracking
and/or dermatitis.
Chronic effects
:
No known significant effects or critical hazards.
Carcinogenicity
:
No known significant effects or critical hazards.
Mutagenicity
No known significant effects or critical hazards.
Teratogenicity
Developmental effects
: No known significant effects or critical hazards.
Fertility effects
: No known significant effects or critical hazards.
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:
Ecological information
United States
Octanol/water partition
coefficient
: 0.82
Environmental effects
: This product shows a low bioaccumulation potential.
Bioconcentration factor
: Not available.
12 .
Aquatic ecotoxicity
Conclusion/Summary
: Not available.
The generation of waste should be avoided or minimized wherever possible. Dispose of
surplus and non-recyclable products via a licensed waste disposal contractor. Disposal
of this product, solutions and any by-products should at all times comply with the
requirements of environmental protection and waste disposal legislation and any regional
local authority requirements. Avoid dispersal of spilled material and runoff and contact
with soil, waterways, drains and sewers.
Code: F039
Waste disposal
Waste stream
Disposal considerations
Disposal should be in accordance with applicable regional, national and local laws and regulations.
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13 .
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
Hazardous waste
: The classification of the product may meet the criteria for a hazardous waste.
Transport information
3
DOT Classification
DIETHYL ETHER OR
ETHYL ETHER
I
DIETHYL ETHER
UN1155
IATA-DGR Class
3
Regulatory
information
UN number
Proper shipping
name
Classes
PG*
I
UN1155
14 .
PG* : Packing group
Flammable liquid
Target organ effects
HCS Classification
Regulatory information
U.S. Federal regulations
TSCA 8(a) PAIR: diethyl ether
TSCA 8(a) IUR: diethyl ether
United States inventory (TSCA 8b): This material is listed or exempted.
TSCA 12(b) annual export notification: diethyl ether
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United States
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Regulatory information
15 .
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean Air Act (CAA) 112 accidental release prevention: diethyl ether
Clean Air Act (CAA) 112 regulated flammable substances: diethyl ether
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
CEPA Toxic substances: This material is not listed.
Canadian ARET: This material is not listed.
Canadian NPRI: This material is not listed.
Alberta Designated Substances: This material is not listed.
Ontario Designated Substances: This material is not listed.
Quebec Designated Substances: This material is not listed.
Australia inventory (AICS): This material is listed or exempted.
China inventory (IECSC): This material is listed or exempted.
Korea inventory (KECI): This material is listed or exempted.
Philippines inventory (PICCS): This material is listed or exempted.
Japan inventory (ENCS): This material is listed or exempted.
WHMIS (Canada)
Class B-2: Flammable liquid
International regulations
International lists
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: diethyl ether
SARA 311/312 MSDS distribution - chemical inventory - hazard identification:
diethyl ether: Fire hazard, Immediate (acute) health hazard, Delayed (chronic) health
hazard
:
:
Canada
EU regulations
Canadian lists
:
Canada inventory
: Canada inventory: This material is listed or exempted.
R12- Extremely flammable.
R19- May form explosive peroxides.
R22- Harmful if swallowed.
R66- Repeated exposure may cause skin dryness or cracking.
R67- Vapors may cause drowsiness and dizziness.
Hazard symbol or symbols
Risk phrases
:
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Extremely flammable, Harmful
:
Other information
Hazardous Material
Information System (U.S.A.)
1
4
1
Health
Flammability
Physical hazards
EXTREMELY FLAMMABLE LIQUID AND VAPOR. FLAMMABLE. VAPOR MAY
CAUSE FLASH FIRE. MAY BE HARMFUL IF SWALLOWED. CAN CAUSE TARGET
ORGAN DAMAGE.
Label requirements
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16 .
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Ether
Other information
16 .
1
4
1
National Fire Protection
Association (U.S.A.)
Health
Special
Instability
Flammability
Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
Date of printing
Date of issue
Date of previous issue
Version
5/16/2008.
5/16/2008.
1.01
No previous validation.
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The customer is responsible for determining the PPE code for this material.
Indicates information that has changed from previously issued version.
Full text of R-phrases
referred to in sections 2 and
3 - Europe
: R12- Extremely flammable.
R19- May form explosive peroxides.
R22- Harmful if swallowed.
R66- Repeated exposure may cause skin dryness or cracking.
R67- Vapors may cause drowsiness and dizziness.
Full text of classifications
referred to in sections 2 and
3 - Europe
: F+ - Extremely flammable
Xn - Harmful
This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the information required by the CPR.
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